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ELEKTİF TOTAL ABDOMİNAL HİSTEREKTOMİ VE BİLATERAL OOFEREKTOMİ YAPILAN HASTALARDA İNTRAOPERATİF FARKLI DOZLARDA UYGULANAN LİDOKAİN İNFÜZYONUN POSTOPERATİF AĞRI KONTROLÜNE VE ANALJEZİ TÜKETİMİNE ETKİLERİNİN GÖZLENMESİ

Year 2020, Volume: 27 Issue: 2, 234 - 241, 01.06.2020
https://doi.org/10.17343/sdutfd.657189

Abstract

Çalışmanın amacı, peroperatif farklı dozlarda uygulanan lidokain infüzyonunun postoperatif analjezi ihtiyacına etkilerini, postoperatif bulantıya ve toplam parasetamol tüketimine etkilerini araştırmak.
Bu çalışmada operasyon süresi 120 dk’ı geçmeyen elektif şartlarda TAH-BSO operasyonu geçiren ve peroperatif lidokain infüzyonu yapılan hastaların medikal ve anestezi kayıtları retrospektif olarak değerlendirildi. 18-65 yaş arası, ASA I-II, VKİ <25 olan hastalar çalışmaya dahil edildi. Dosya kayıtları incelenen hastalar 3 gruba ayrıldı; Grup L1: 1.5 mg/kg lidokain infüzyon yapılan hastalar, Grup L2: 3 mg/kg lidokain infüzyon yapılan hastalar ve Grup S: sadece SF infüzyon yapılan hastalar. Değerlendirilen dosyalardan 3 mg/kg/h lidokain infüzyonu yapılan 3 hastada bradikardi geliştiği için lidokain infüzyonunun kesildiği saptandı ve çalışma dışı bırakıldı. Hastaların anestezi takip fişlerinden hemodinamik parametreler, demografik veriler, algoloji takip formlarından postoperatif VAS skorları, bulantı, ilk mobilizasyon zamanı ve toplam parasetamol tüketimi kaydedildi.
Demografik ve hemodinamik veriler açısından gruplar arasında fark bulunmadı. Postoperatif 2, 6 ve 14. saat VAS değerleri Grup L1’de Grup S’e göre anlamlı olarak daha düşük bulundu (p<0,001). Hastaların postoperatif 6, 10 ve 14. saatteki bulantısı Grup S’de diğer gruplara göre anlamlı olarak daha yüksek bulundu (p<0.05). İlk analjezi zamanlarına bakıldığında da Grup L1’de Grup S’e göre ilk parasetamol zamanı anlamlı olarak daha geç bulundu (p=0.008).
Sonuç olarak 3 mg/kg lidokain infüzyonun postopeartif VAS skorlarını düşürdüğünü ancak bradikardi yapma olasılığının olduğunu, 1.5 mg/kg lidokain infüzyon dozlarının postoperatif analjezik etki sağladığını ve yan etki insidansını da azalttığını düşünmekteyiz

Supporting Institution

Bu araştırma Süleyman Demirel Üniversitesi Bilimsel Araştırma Projeleri yönetim birimince desteklenmiştir

Project Number

4743-TU1-16 no’lu proje numaras

Thanks

Süleyman Demirel Üniversitesi Bilimsel Araştırma Projeleri Koordinasyon birimine desteklerinden dolayı teşekkür ederiz.

References

  • Rferans 1. Max MB, Donovan M, Miaskowski CA . American Pain Society Quality of Care Committee: Quality improved guidelines for the treatment of acute pain and cancer pain. JAMA 1995;274: 1874-80.
  • Referans 2. Kehlet H, Dahl JB. The value of multimodal or balanced analgesia in postoperative pain treatment. Anesth Analg 1993;77(5):1048-56.
  • Referans 3. Shankar RS, Wilson JA, Colvin L. Non-opioid-based adjuvant analgesia in perioperative care. Br J Anaesth. 2013;13(5):152-157.
  • Referans 4. De Oliveira CM, Issy AM, Sakata RK. intraoperative intravenous lidocaine. Rev Bras Anestesiol 2010;60(3):325-33.
  • Referans 5. Kuo CP, Jao SW, Chen KM, Wong CS, Yeh CC, Sheen MC. Comparison of the effects of thoracic epidural analgesia and i.v. infusion with lidocaine on cytokine response, postoperative pain and bowel function in patients undergoing colonicsurgery. Br J Anaesth 2006;97: 640-6.
  • Referans 6. McCarthy C, Sohair A, Achraf S. Impact of ıntravenous lidocaine infusion on postoperative analgesia and recovery from surgery. Drugs 2010;70(9):1149- 1163.
  • Referans 7. Marret E, Rolin M, Beaussier M, Bonnet F. Meta-analysis of intravenous lidocaine and postoperative recovery after abdominal surgery. Br J Surgery 2008;95(11):1331-1338.
  • Referans 8. Bryson GL, Charapov I, Krolczyk G, Taljaard M, Reid D. Intravenous lidocaine does not reduce length of hospital stay following abdominal hysterectomy. Can J Anaesth. 2010;57(8): 759-66.
  • Referans 9. Wang T, Lıu H, Sun JH; Wang L. Efficacy of intravenous lidocaine in improving post-operative nausea,vomiting and early recovery after laparoscopic gynaecological surgery,experimental and therapeutic medicine 2019;17(6):4723-4729.
  • Referans 10. Michael A. Ramsay E. Acute postoperative pain management. BUMC 2000;13:244–224.
  • Referans 11. Mac Intyre P. General Surgery. In: Alman KG, Wilson HI. (Eds.). Oxford Handbook of anaesthesia. New York: Oxford University Pres, 2002;277-98.
  • Referans 12. Jin F, Chung F. Multimodal Analgesia for postoperative pain control. J Clin Anesth.2001; 13:524-39.
  • Referans 13. Chou R, Gordon DB, de Leon-Casasola OA, Rosenberg JM, BicklerS, Brennan T et al. Management of Postoperative Pain: A Clinical Practice Guideline From the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists' Committee on Regional Anesthesia. J of Pain. 2016;17(2): 131-57.
  • Referans 14. Koppert W, Weigand M, Neumann F. Perioperative intravenous lidocaine has preventive effects on postoperative pain and morphine consumption after major abdominal surgery. Anesth Analg 2004;98:1050-1055.
  • Referans 15. Herroeder S, Pecher S, Schönherr E. Systemic lidocaine shortens length of hospital stay after colorectal surgery. Ann Surg 2007;246:192-200.
  • Referans 16. Terkawi AS, Tsang S, Kazemi A, Morton S, Luo R, Sanders DT, et al. A clinical comparison of intravenous and epidural local anesthetic for major abdominal surgery. Reg Anesth Pain Med 2016;41:28–36.
  • Referans 17. Cui W, Li Y, Li S, Wang R, Li J. Systemic administration of lidocaine reduces morphine requirements and postoperative pain of patients undergoing thoracic surgery after propofol-remifentanil-based anaesthesia. Eur J Anaesthesiol 2010;27:41–6.
  • Referans 18. Farag E, Ghobrial M, Sessler DI, Dalton JE, Liu J, Lee JH. Effect of perioperative intravenous lidocaine administration on pain, opioid consumption, and quality of life after complex spine surgery. Anesthesiology. 2013;119(4):932-40.
  • Referans 19. Grigoras A, Lee P, Sattar F, Shorten G. Perioperative intravenous lidocaine decreases the incidence of persistent pain after breast surgery. Clin J Pain 2012;28:567–72.
  • Referans 20. Kayaalp O. Tıbbi Farmakoloji. 11. Baskı, Ankara: Hacettepe Taş Kitapçılık,2005;680-693.
  • Referans 21. Wallin G, Cassuto J, Hogstrom S, Linden I, Faxen A, Rimback G et al. Effects of lidocaine infusion on the sympathetic response to abdominal surgery. Anesth Analg 1987;66: 1008-13.
  • Referans 22. Dogan SD, Ustun FE, Sener EB, Koksal E, Ustun YB, Kaya C, et al. Effects of lidocaine and esmolol infusions on hemedynamic changes analgesic requirement and recovery in laparoscopic cholecystectomy operations. Braz J Anesthesiol. 2016;66(2):145-50.
  • Referans 23. Groudine SB, Fisher HA, Kaufman RP, Hugh A,Ronald I, Manoj K. Intravenous lidocaine speeds the return of bowel function, decreases postoperative pain, and shortens hospital stay in patients undergoing radical retropubic prostatectomy. Anesth Analg 1998;86:235–9.
  • Referans 24. Swenson BR, Gottschalk A, Wells LT, Rowlingson JC, Thompson PW, Barclay M et al. Intravenous lidocaine is as effective as epidural bupivacaine in reducing ileus duration, hospital stay, and pain after open colon resection: A randomized clinical trial. Reg Anesth Pain Med 2010;35:370–6.
  • Referans 25. Yardeni IZ, Beilin B, Mayburd E, Levinson Y, Bessler H. The effect of perioperative intravenous lidocaine on postoperative pain and immune function. Anesth Analg. 2009;109(5): 1464-9.
  • Referans 26. Rimbäck G, Cassuto J, Tollesson PO. Treatment of postoperative paralytic ileus by intravenous lidocaine infusion. Anesth Analg. 1990;70(4):414-9.
  • Referans 27. Boitano T, Smith H, Rushton T, Johnston M, Lawson P, Leath C et al. Impact of enhanced recovery after surgery (ERAS) protocol on gastrointestinal function in gynecologic oncology patients undergoing laparotomy. Gynecologic Oncology. 2018;151(2):282-286.
  • Referans 28. Zengin S, Saracoglu A, Eti Z, Umuroglu T, Gogus F. The Effects of Preoperative Oral Pregabalin and Perioperative Intravenous Lidocaine Infusion on Postoperative Morphine Requirement in Patients Undergoing Laparatomy. Pain Res Manag. 2015; 20(4):179-82.
  • Referans 29. Ahn E, Kang H, Choi GJ, Park YH, Yang SY, Kim BG, et al. Intravenous lidocaine for effective pain relief after a laparoscopic colectomy: a prospective, randomized, double-blind, placebo-controlled study. Int Surg. 2015;100(3):394-401.
  • Referans 30. Kaba A, Laurent SR, Detroz BJ, Sessler DI, Durieux ME, Lamy ML et al. Intravenous lidocaine infusion facilitates acute rehabilitation laparoscopic colectomy. Anesthesiology 2007;106: 11–8.
Year 2020, Volume: 27 Issue: 2, 234 - 241, 01.06.2020
https://doi.org/10.17343/sdutfd.657189

Abstract

Project Number

4743-TU1-16 no’lu proje numaras

References

  • Rferans 1. Max MB, Donovan M, Miaskowski CA . American Pain Society Quality of Care Committee: Quality improved guidelines for the treatment of acute pain and cancer pain. JAMA 1995;274: 1874-80.
  • Referans 2. Kehlet H, Dahl JB. The value of multimodal or balanced analgesia in postoperative pain treatment. Anesth Analg 1993;77(5):1048-56.
  • Referans 3. Shankar RS, Wilson JA, Colvin L. Non-opioid-based adjuvant analgesia in perioperative care. Br J Anaesth. 2013;13(5):152-157.
  • Referans 4. De Oliveira CM, Issy AM, Sakata RK. intraoperative intravenous lidocaine. Rev Bras Anestesiol 2010;60(3):325-33.
  • Referans 5. Kuo CP, Jao SW, Chen KM, Wong CS, Yeh CC, Sheen MC. Comparison of the effects of thoracic epidural analgesia and i.v. infusion with lidocaine on cytokine response, postoperative pain and bowel function in patients undergoing colonicsurgery. Br J Anaesth 2006;97: 640-6.
  • Referans 6. McCarthy C, Sohair A, Achraf S. Impact of ıntravenous lidocaine infusion on postoperative analgesia and recovery from surgery. Drugs 2010;70(9):1149- 1163.
  • Referans 7. Marret E, Rolin M, Beaussier M, Bonnet F. Meta-analysis of intravenous lidocaine and postoperative recovery after abdominal surgery. Br J Surgery 2008;95(11):1331-1338.
  • Referans 8. Bryson GL, Charapov I, Krolczyk G, Taljaard M, Reid D. Intravenous lidocaine does not reduce length of hospital stay following abdominal hysterectomy. Can J Anaesth. 2010;57(8): 759-66.
  • Referans 9. Wang T, Lıu H, Sun JH; Wang L. Efficacy of intravenous lidocaine in improving post-operative nausea,vomiting and early recovery after laparoscopic gynaecological surgery,experimental and therapeutic medicine 2019;17(6):4723-4729.
  • Referans 10. Michael A. Ramsay E. Acute postoperative pain management. BUMC 2000;13:244–224.
  • Referans 11. Mac Intyre P. General Surgery. In: Alman KG, Wilson HI. (Eds.). Oxford Handbook of anaesthesia. New York: Oxford University Pres, 2002;277-98.
  • Referans 12. Jin F, Chung F. Multimodal Analgesia for postoperative pain control. J Clin Anesth.2001; 13:524-39.
  • Referans 13. Chou R, Gordon DB, de Leon-Casasola OA, Rosenberg JM, BicklerS, Brennan T et al. Management of Postoperative Pain: A Clinical Practice Guideline From the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists' Committee on Regional Anesthesia. J of Pain. 2016;17(2): 131-57.
  • Referans 14. Koppert W, Weigand M, Neumann F. Perioperative intravenous lidocaine has preventive effects on postoperative pain and morphine consumption after major abdominal surgery. Anesth Analg 2004;98:1050-1055.
  • Referans 15. Herroeder S, Pecher S, Schönherr E. Systemic lidocaine shortens length of hospital stay after colorectal surgery. Ann Surg 2007;246:192-200.
  • Referans 16. Terkawi AS, Tsang S, Kazemi A, Morton S, Luo R, Sanders DT, et al. A clinical comparison of intravenous and epidural local anesthetic for major abdominal surgery. Reg Anesth Pain Med 2016;41:28–36.
  • Referans 17. Cui W, Li Y, Li S, Wang R, Li J. Systemic administration of lidocaine reduces morphine requirements and postoperative pain of patients undergoing thoracic surgery after propofol-remifentanil-based anaesthesia. Eur J Anaesthesiol 2010;27:41–6.
  • Referans 18. Farag E, Ghobrial M, Sessler DI, Dalton JE, Liu J, Lee JH. Effect of perioperative intravenous lidocaine administration on pain, opioid consumption, and quality of life after complex spine surgery. Anesthesiology. 2013;119(4):932-40.
  • Referans 19. Grigoras A, Lee P, Sattar F, Shorten G. Perioperative intravenous lidocaine decreases the incidence of persistent pain after breast surgery. Clin J Pain 2012;28:567–72.
  • Referans 20. Kayaalp O. Tıbbi Farmakoloji. 11. Baskı, Ankara: Hacettepe Taş Kitapçılık,2005;680-693.
  • Referans 21. Wallin G, Cassuto J, Hogstrom S, Linden I, Faxen A, Rimback G et al. Effects of lidocaine infusion on the sympathetic response to abdominal surgery. Anesth Analg 1987;66: 1008-13.
  • Referans 22. Dogan SD, Ustun FE, Sener EB, Koksal E, Ustun YB, Kaya C, et al. Effects of lidocaine and esmolol infusions on hemedynamic changes analgesic requirement and recovery in laparoscopic cholecystectomy operations. Braz J Anesthesiol. 2016;66(2):145-50.
  • Referans 23. Groudine SB, Fisher HA, Kaufman RP, Hugh A,Ronald I, Manoj K. Intravenous lidocaine speeds the return of bowel function, decreases postoperative pain, and shortens hospital stay in patients undergoing radical retropubic prostatectomy. Anesth Analg 1998;86:235–9.
  • Referans 24. Swenson BR, Gottschalk A, Wells LT, Rowlingson JC, Thompson PW, Barclay M et al. Intravenous lidocaine is as effective as epidural bupivacaine in reducing ileus duration, hospital stay, and pain after open colon resection: A randomized clinical trial. Reg Anesth Pain Med 2010;35:370–6.
  • Referans 25. Yardeni IZ, Beilin B, Mayburd E, Levinson Y, Bessler H. The effect of perioperative intravenous lidocaine on postoperative pain and immune function. Anesth Analg. 2009;109(5): 1464-9.
  • Referans 26. Rimbäck G, Cassuto J, Tollesson PO. Treatment of postoperative paralytic ileus by intravenous lidocaine infusion. Anesth Analg. 1990;70(4):414-9.
  • Referans 27. Boitano T, Smith H, Rushton T, Johnston M, Lawson P, Leath C et al. Impact of enhanced recovery after surgery (ERAS) protocol on gastrointestinal function in gynecologic oncology patients undergoing laparotomy. Gynecologic Oncology. 2018;151(2):282-286.
  • Referans 28. Zengin S, Saracoglu A, Eti Z, Umuroglu T, Gogus F. The Effects of Preoperative Oral Pregabalin and Perioperative Intravenous Lidocaine Infusion on Postoperative Morphine Requirement in Patients Undergoing Laparatomy. Pain Res Manag. 2015; 20(4):179-82.
  • Referans 29. Ahn E, Kang H, Choi GJ, Park YH, Yang SY, Kim BG, et al. Intravenous lidocaine for effective pain relief after a laparoscopic colectomy: a prospective, randomized, double-blind, placebo-controlled study. Int Surg. 2015;100(3):394-401.
  • Referans 30. Kaba A, Laurent SR, Detroz BJ, Sessler DI, Durieux ME, Lamy ML et al. Intravenous lidocaine infusion facilitates acute rehabilitation laparoscopic colectomy. Anesthesiology 2007;106: 11–8.
There are 30 citations in total.

Details

Primary Language Turkish
Subjects Surgery
Journal Section Research Articles
Authors

Dudu Gül

Filiz Alkaya Solmaz 0000-0001-5772-6708

Pakize Kırdemir

Project Number 4743-TU1-16 no’lu proje numaras
Publication Date June 1, 2020
Submission Date December 10, 2019
Acceptance Date January 30, 2020
Published in Issue Year 2020 Volume: 27 Issue: 2

Cite

Vancouver Gül D, Alkaya Solmaz F, Kırdemir P. ELEKTİF TOTAL ABDOMİNAL HİSTEREKTOMİ VE BİLATERAL OOFEREKTOMİ YAPILAN HASTALARDA İNTRAOPERATİF FARKLI DOZLARDA UYGULANAN LİDOKAİN İNFÜZYONUN POSTOPERATİF AĞRI KONTROLÜNE VE ANALJEZİ TÜKETİMİNE ETKİLERİNİN GÖZLENMESİ. Med J SDU. 2020;27(2):234-41.

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