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Bakla (Fabasea) mı Suçlu Genleriniz mi?

Year 2021, Volume: 4 Issue: 3, 42 - 53, 30.12.2021

Cahit Erkul Aliye Özenoğlu

https://doi.org/10.51536/tusbad.985503

Abstract

Glikoz-6-fosfat dehidrogenaz (G6PD) eksikliği, dünya çapında en az 400 milyon kişiyi etkileyen, dünyadaki en yaygın enzim eksikliğidir. Bu metabolik enzim, eritrositlerin oksidatif strese karşı korunmasında önemli bir rol oynar, böylece hemoliz önlenir. Tarihsel olarak, baklanın (fabasea) tüketilmeye başlanmasından sonra patolojik bir bozukluk fark edilmiş, daha sonra bu durum G6PD eksikliği olarak tanımlanmıştır. Eksik G6PD alelleri dünya çapında görülmektedir. Fabasea meyvesinin içerdiği besin öğeleri incelendiğinde, proteinler, karbonhidratlar, suda çözünen vitaminler (folik asit, niasin ve C vitamini), diyet lifi açısından zengin olduğunu ortaya konulmuştur. Favizm, bakla tüketiminden kaynaklanan hemolitik anemiyi tanımlamak için kullanılan bir terimdir. G6PD eksikliği ile ilişkisi bilimsel ve tıbbi literatürde yer almıştır. Nutrigenetik, hastalık etiyolojisinde rol oynayabilecek beslenme ve genetik faktörlerin etkileşimi ile ilgilidir. Bu derlemenin amacı G6PD eksikliğinin patofizyolojisi, genetik özellikleri ve favizm ile ilişkisini ortaya koymak ve genetik yapıya göre beslenmenin (nutrigenetik) önemine vurgu yapmaktır.

Keywords

Fabasea favizm nutrigenetik

References

  • 1. Luzzatto L, & Arese P. Favism and glucose-6-phosphate dehydrogenase deficiency. New England Journal of Medicine. 2018; 378(1): 60-71. doi:10.1056/NEJMra170811.
  • 2. Nkhoma ET, Poole C, Vannappagari V, Hall SA, & Beutler E. The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis. Blood Cells, Molecules, and Diseases. 2009;42(3): 267-278. doi:10.1016/j.bcmd.2008.12.005.
  • 3. Wajcman H, & Galactéros F. Glucose 6-phosphate dehydrogenase deficiency: a protection against malaria and a risk for hemolytic accidents. Comptes Rendus Biologies, 2004; 327(8): 711-720. doi:10.1016/j.crvi.2004.07.010.
  • 4. Gómez-Manzo S, Marcial-Quino J, Vanoye-Carlo A, et al. Glucose-6-phosphate dehydrogenase: update and analysis of new mutations around the world. International Journal of Molecular Sciences. 2016;17(12): 2069. doi:10.3390/ijms17122069.
  • 5. Carson PE, Flanagan CL, Ickes CE, & Alving AS. Enzymatic deficiency in primaquine-sensitive erythrocytes. Science. 1956; 124(3220): 484-485. doi:10.1126/science.124.3220.484-a.
  • 6. Ravikumar N & Greenfield G. Glucose-6-phosphate Dehydrogenase Deficiency: A Review. International Journal of Medical Students. 2020;8(3): 281-287. doi:10.5195/ijms.2020.637.
  • 7. Mehta AB. Glucose-6-phosphate dehydrogenase deficiency. Postgraduate Medical Journal. 1994; 70(830); 871. doi:10.1136/pgmj.70.830.871.
  • 8. Deng Z, Yang F, Bai Y, et al. Co-inheritance of glucose-6-phosphate dehydrogenase deficiency mutations and hemoglobin E in a Kachin population in a malaria-endemic region of Southeast Asia. PloS One. 2017;12(5): e0177917. doi:10.1371/journal.pone.0177917.
  • 9. Gómez-Manzo S, Marcial-Quino J, Vanoye-Carlo A, et al. Glucose-6-phosphate dehydrogenase: update and analysis of new mutations around the world. International Journal of Molecular Sciences. 2016; 17(12): 2069. doi:10.3390/ijms17122069.
  • 10. Beutler E. Glucose-6-phosphate dehydrogenase deficiency: a historical perspective. Blood. 2008; 111(1): 16-24. doi:10.1182/blood-2007-04-077412.
  • 11. Frank JE. Diagnosis and management of G6PD deficiency. American Family Physician. 2005;72(7):1277-1282. https://www.aafp.org/afp/2005/1001/afp20051001p1277.pdf. 8 Temmuz 2021’de erişildi.
  • 12. Cappellini MD, Sampietro M, Toniolo D, et al. (1994). G6PD Ferrara I has the same two mutations as G6PD A (-) but a distinct biochemical phenotype. Human Genetics, 1994; 93(2): 139-142. https://link.springer.com/content/pdf/10.1007/BF00210598.pdf. 8 Temmuz 2021’de erişildi.
  • 13. Luzzatto L, Ally M, & Notaro R. Glucose-6-phosphate dehydrogenase deficiency. Blood, The Journal of the American Society of Hematology. 2020; 136(11): 1225-1240. doi:10.1182/blood.2019000944.
  • 14. Iriti M, Varoni EM. Pulses, healthy, and sustainable food sources for feeding the planet. International Journal of Molecular Sciences. 2017; 18(2): 255-256. doi:10.3390/ijms18020255.
  • 15. Vioque J, Alaiz M, Girón-Calle J. Nutritional and functional properties of Vicia faba protein isolates and related fractions. Food Chemistry.2012; 132(1): 67-72. doi:10.1016/j.foodchem.2011.10.033.
  • 16. Prabhu SD, Rajeswari DV. Nutritional and Biological properties of Vicia faba L.: A perspective review. International Food Research Journal. 2018; 25(4): 1332-1340. http://ifrj.upm.edu.my/25%20(04)%202018/(2).pdf 8 Temmuz 2021’de erişildi.
  • 17. Coda R, Melama L, Rizzello CG, et al. Effect of air classification and fermentation by Lactobacillus plantarum VTT E-133328 on faba bean (Vicia faba L.) flour nutritional properties. International Journal of Food Microbiology. 2015; 193: 34-42. doi:10.1016/j.ijfoodmicro.2014.10.012.
  • 18. Song M. Preventing favism by selecting faba bean mutants using molecular markers. STEM Fellowship Journal.2017; 3(1): 2-6. doi:10.17975/sfj-2017-001.
  • 19. Arese P, Gallo V, Pantaleo A, Turrini F. Life and death of glucose-6-phosphate dehydrogenase (G6PD) deficient erythrocytes–role of redox stress and band 3 modifications. Transfusion Medicine and Hemotherapy. 2012; 39(5): 328-334. doi:10.1159/000343123.
  • 20. Getachew F, Vandenberg A, Smits J. A practical toxicity bioassay for vicine and convicine levels in faba bean (Vicia faba). Journal of the Science of Food and Agriculture. 2018; 98(13): 5105-5111. doi:10.1002/jsfa.9049.
  • 21. Ahmed SN. Do favic patients resume fava beans ingestion later in their life, a study for this, and a new hypothesis for favism etiology. Hematology/Oncology and Stem Cell Therapy.2013; 6(1): 9-13. doi: 10.1016/j.hemonc.2013.03.002.
  • 22. Al-Mendalawi MD. A hemolysis trigger in glucose-6-phosphate dehydrogenase enzyme deficiency. Vicia sativa (vetch). Saudi Medical Journal. 2009;30(7): 974-975. https://www.researchgate.net/profile/Mahmood-Al-Mendalawi/publication/26681776_A_hemolysis_trigger_in_glucose-6-phosphate_dehydrogenase_enzyme_deficiency_Vicia_sativa_vetch/links/00b7d52907eef6d72a000000/A-hemolysis-trigger-in-glucose-6-phosphate-dehydrogenase-enzyme-deficiency-Vicia-sativa-vetch.pdf. 8 Temmuz 2021’de erişildi.
  • 23. Cappellini MD, Fiorelli G. Glucose-6-phosphate dehydrogenase deficiency. The Lancet. 2008; 371(9606): 64-74. doi:10.1016/S0140-6736(08)60073-2.
  • 24. Marcum JA. Nutrigenetics/nutrigenomics, personalized nutrition, and precision healthcare. Current Nutrition Reports. 2020; 9(4): 338-345. doi:10.1007/s13668-020-00327-z.
  • 25. Bouchard C, Ordovas JM. Fundamentals of Nutrigenetics and Nutrigenomics. Progress in Molecular Biology and Translational Science.2012; 108:1–15. doi:10.1016/B978-0-12-398397-8.00001-0.
  • 26. Sharma P, Dwivedi S. Nutrigenomics and nutrigenetics: New insight in disease prevention and cure. Indian Journal of Clinical Biochemistry.2017; 32(4): 371–373. doi:10.1007/s12291-017-0699-5.
  • 27. Barak S, Mudgil D, Khatkar BS. Nutrigenomics: the emerging face of nutrition. International Journal of Current Research and Review. 2011;3(6):105-115. https://www.ijcrr.com/article_html.php?did=2166&issueno=0. 8 Temmuz 2021’de erişildi.

Which is Guilty? Fabaceae or Your Genes

Year 2021, Volume: 4 Issue: 3, 42 - 53, 30.12.2021

Cahit Erkul Aliye Özenoğlu

https://doi.org/10.51536/tusbad.985503

Abstract

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency in the world, affecting at least 400 million people worldwide.This metabolic enzyme plays an important role in protecting erythrocytes against oxidative stress, thus preventing hemolysis. Historically, a pathological disorder was noticed after the consumption of fabaceae, which was later defined as G6PD deficiency. Missing G6PD alleles occur worldwide. When the nutritional elements of the fabaceae fruit were examined, it was revealed that it is rich in proteins, carbohydrates, water-soluble vitamins (folic acid, niacin and vitamin C), dietary fiber. Favism is a term used to describe hemolytic anemia caused by consumption of fabaceae. Its association with G6PD deficiency has been reported in the scientific and medical literature. Nutrigenetics is concerned with the interaction of nutrition and genetic factors that may play a role in disease etiology. The aim of this review is to reveal the pathophysiology of G6PD deficiency, its genetic characteristics and its relationship with favism, and to emphasize the importance of nutrition (nutrigenetics) according to genetic structure.

References

  • 1. Luzzatto L, & Arese P. Favism and glucose-6-phosphate dehydrogenase deficiency. New England Journal of Medicine. 2018; 378(1): 60-71. doi:10.1056/NEJMra170811.
  • 2. Nkhoma ET, Poole C, Vannappagari V, Hall SA, & Beutler E. The global prevalence of glucose-6-phosphate dehydrogenase deficiency: a systematic review and meta-analysis. Blood Cells, Molecules, and Diseases. 2009;42(3): 267-278. doi:10.1016/j.bcmd.2008.12.005.
  • 3. Wajcman H, & Galactéros F. Glucose 6-phosphate dehydrogenase deficiency: a protection against malaria and a risk for hemolytic accidents. Comptes Rendus Biologies, 2004; 327(8): 711-720. doi:10.1016/j.crvi.2004.07.010.
  • 4. Gómez-Manzo S, Marcial-Quino J, Vanoye-Carlo A, et al. Glucose-6-phosphate dehydrogenase: update and analysis of new mutations around the world. International Journal of Molecular Sciences. 2016;17(12): 2069. doi:10.3390/ijms17122069.
  • 5. Carson PE, Flanagan CL, Ickes CE, & Alving AS. Enzymatic deficiency in primaquine-sensitive erythrocytes. Science. 1956; 124(3220): 484-485. doi:10.1126/science.124.3220.484-a.
  • 6. Ravikumar N & Greenfield G. Glucose-6-phosphate Dehydrogenase Deficiency: A Review. International Journal of Medical Students. 2020;8(3): 281-287. doi:10.5195/ijms.2020.637.
  • 7. Mehta AB. Glucose-6-phosphate dehydrogenase deficiency. Postgraduate Medical Journal. 1994; 70(830); 871. doi:10.1136/pgmj.70.830.871.
  • 8. Deng Z, Yang F, Bai Y, et al. Co-inheritance of glucose-6-phosphate dehydrogenase deficiency mutations and hemoglobin E in a Kachin population in a malaria-endemic region of Southeast Asia. PloS One. 2017;12(5): e0177917. doi:10.1371/journal.pone.0177917.
  • 9. Gómez-Manzo S, Marcial-Quino J, Vanoye-Carlo A, et al. Glucose-6-phosphate dehydrogenase: update and analysis of new mutations around the world. International Journal of Molecular Sciences. 2016; 17(12): 2069. doi:10.3390/ijms17122069.
  • 10. Beutler E. Glucose-6-phosphate dehydrogenase deficiency: a historical perspective. Blood. 2008; 111(1): 16-24. doi:10.1182/blood-2007-04-077412.
  • 11. Frank JE. Diagnosis and management of G6PD deficiency. American Family Physician. 2005;72(7):1277-1282. https://www.aafp.org/afp/2005/1001/afp20051001p1277.pdf. 8 Temmuz 2021’de erişildi.
  • 12. Cappellini MD, Sampietro M, Toniolo D, et al. (1994). G6PD Ferrara I has the same two mutations as G6PD A (-) but a distinct biochemical phenotype. Human Genetics, 1994; 93(2): 139-142. https://link.springer.com/content/pdf/10.1007/BF00210598.pdf. 8 Temmuz 2021’de erişildi.
  • 13. Luzzatto L, Ally M, & Notaro R. Glucose-6-phosphate dehydrogenase deficiency. Blood, The Journal of the American Society of Hematology. 2020; 136(11): 1225-1240. doi:10.1182/blood.2019000944.
  • 14. Iriti M, Varoni EM. Pulses, healthy, and sustainable food sources for feeding the planet. International Journal of Molecular Sciences. 2017; 18(2): 255-256. doi:10.3390/ijms18020255.
  • 15. Vioque J, Alaiz M, Girón-Calle J. Nutritional and functional properties of Vicia faba protein isolates and related fractions. Food Chemistry.2012; 132(1): 67-72. doi:10.1016/j.foodchem.2011.10.033.
  • 16. Prabhu SD, Rajeswari DV. Nutritional and Biological properties of Vicia faba L.: A perspective review. International Food Research Journal. 2018; 25(4): 1332-1340. http://ifrj.upm.edu.my/25%20(04)%202018/(2).pdf 8 Temmuz 2021’de erişildi.
  • 17. Coda R, Melama L, Rizzello CG, et al. Effect of air classification and fermentation by Lactobacillus plantarum VTT E-133328 on faba bean (Vicia faba L.) flour nutritional properties. International Journal of Food Microbiology. 2015; 193: 34-42. doi:10.1016/j.ijfoodmicro.2014.10.012.
  • 18. Song M. Preventing favism by selecting faba bean mutants using molecular markers. STEM Fellowship Journal.2017; 3(1): 2-6. doi:10.17975/sfj-2017-001.
  • 19. Arese P, Gallo V, Pantaleo A, Turrini F. Life and death of glucose-6-phosphate dehydrogenase (G6PD) deficient erythrocytes–role of redox stress and band 3 modifications. Transfusion Medicine and Hemotherapy. 2012; 39(5): 328-334. doi:10.1159/000343123.
  • 20. Getachew F, Vandenberg A, Smits J. A practical toxicity bioassay for vicine and convicine levels in faba bean (Vicia faba). Journal of the Science of Food and Agriculture. 2018; 98(13): 5105-5111. doi:10.1002/jsfa.9049.
  • 21. Ahmed SN. Do favic patients resume fava beans ingestion later in their life, a study for this, and a new hypothesis for favism etiology. Hematology/Oncology and Stem Cell Therapy.2013; 6(1): 9-13. doi: 10.1016/j.hemonc.2013.03.002.
  • 22. Al-Mendalawi MD. A hemolysis trigger in glucose-6-phosphate dehydrogenase enzyme deficiency. Vicia sativa (vetch). Saudi Medical Journal. 2009;30(7): 974-975. https://www.researchgate.net/profile/Mahmood-Al-Mendalawi/publication/26681776_A_hemolysis_trigger_in_glucose-6-phosphate_dehydrogenase_enzyme_deficiency_Vicia_sativa_vetch/links/00b7d52907eef6d72a000000/A-hemolysis-trigger-in-glucose-6-phosphate-dehydrogenase-enzyme-deficiency-Vicia-sativa-vetch.pdf. 8 Temmuz 2021’de erişildi.
  • 23. Cappellini MD, Fiorelli G. Glucose-6-phosphate dehydrogenase deficiency. The Lancet. 2008; 371(9606): 64-74. doi:10.1016/S0140-6736(08)60073-2.
  • 24. Marcum JA. Nutrigenetics/nutrigenomics, personalized nutrition, and precision healthcare. Current Nutrition Reports. 2020; 9(4): 338-345. doi:10.1007/s13668-020-00327-z.
  • 25. Bouchard C, Ordovas JM. Fundamentals of Nutrigenetics and Nutrigenomics. Progress in Molecular Biology and Translational Science.2012; 108:1–15. doi:10.1016/B978-0-12-398397-8.00001-0.
  • 26. Sharma P, Dwivedi S. Nutrigenomics and nutrigenetics: New insight in disease prevention and cure. Indian Journal of Clinical Biochemistry.2017; 32(4): 371–373. doi:10.1007/s12291-017-0699-5.
  • 27. Barak S, Mudgil D, Khatkar BS. Nutrigenomics: the emerging face of nutrition. International Journal of Current Research and Review. 2011;3(6):105-115. https://www.ijcrr.com/article_html.php?did=2166&issueno=0. 8 Temmuz 2021’de erişildi.
There are 27 citations in total.

Details

Primary Language Turkish
Subjects Health Care Administration
Journal Section Derleme
Authors

Cahit Erkul

Aliye Özenoğlu 0000-0003-3101-7342

Publication Date December 30, 2021
Published in Issue Year 2021 Volume: 4 Issue: 3

Cite

APA Erkul, C., & Özenoğlu, A. (2021). Bakla (Fabasea) mı Suçlu Genleriniz mi?. Türkiye Sağlık Bilimleri Ve Araştırmaları Dergisi, 4(3), 42-53. https://doi.org/10.51536/tusbad.985503
AMA Erkul C, Özenoğlu A. Bakla (Fabasea) mı Suçlu Genleriniz mi?. Türkiye Sağlık Bilimleri ve Araştırmaları Dergisi. December 2021;4(3):42-53. doi:10.51536/tusbad.985503
Chicago Erkul, Cahit, and Aliye Özenoğlu. “Bakla (Fabasea) Mı Suçlu Genleriniz Mi?”. Türkiye Sağlık Bilimleri Ve Araştırmaları Dergisi 4, no. 3 (December 2021): 42-53. https://doi.org/10.51536/tusbad.985503.
EndNote Erkul C, Özenoğlu A (December 1, 2021) Bakla (Fabasea) mı Suçlu Genleriniz mi?. Türkiye Sağlık Bilimleri ve Araştırmaları Dergisi 4 3 42–53.
IEEE C. Erkul and A. Özenoğlu, “Bakla (Fabasea) mı Suçlu Genleriniz mi?”, Türkiye Sağlık Bilimleri ve Araştırmaları Dergisi, vol. 4, no. 3, pp. 42–53, 2021, doi: 10.51536/tusbad.985503.
ISNAD Erkul, Cahit - Özenoğlu, Aliye. “Bakla (Fabasea) Mı Suçlu Genleriniz Mi?”. Türkiye Sağlık Bilimleri ve Araştırmaları Dergisi 4/3 (December 2021), 42-53. https://doi.org/10.51536/tusbad.985503.
JAMA Erkul C, Özenoğlu A. Bakla (Fabasea) mı Suçlu Genleriniz mi?. Türkiye Sağlık Bilimleri ve Araştırmaları Dergisi. 2021;4:42–53.
MLA Erkul, Cahit and Aliye Özenoğlu. “Bakla (Fabasea) Mı Suçlu Genleriniz Mi?”. Türkiye Sağlık Bilimleri Ve Araştırmaları Dergisi, vol. 4, no. 3, 2021, pp. 42-53, doi:10.51536/tusbad.985503.
Vancouver Erkul C, Özenoğlu A. Bakla (Fabasea) mı Suçlu Genleriniz mi?. Türkiye Sağlık Bilimleri ve Araştırmaları Dergisi. 2021;4(3):42-53.
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