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SIGNIFICANT SYMPTOMATIC RESPONSE TO LITHIUM THERAPY: A CASE OF KLEINE-LEVIN SYNDROME

Year 2019, Volume: 2 Issue: 3, 135 - 140, 29.12.2019

Abstract

Kleine-Levin syndrome (KLS) is a rare disease of unknown etiology. Pathophysiological hypotheses include hypothalamic dysfunction and abnormalities in central serotonin and dopamine metabolism. Some clinical features and study findings support a possible autoimmune process. Although there is no definite treatment defined, various mood stabilizing agents have been used in the treatment because of its episodic course and some behavioral characteristics during the episodes. Lithium can be used for this purpose and has been shown to be effective. In this case report, we present a female patient who had been diagnosed with KLS for many years and was diagnosed late, who had benefited from lithium treatment.

References

  • AlShareef SM., Smith RM., Bahammam AS. (2018). Kleine-Levin syndrome: clues to aetiology. Sleep Breath, 22(3), 613-623.
  • Panda S. (2017). Kleine-Levin syndrome: A neurological rarity. Neurol India, 65(4), 873-878.
  • Dauvilliers Y., Mayer G., Lecendreux M., Neidhart E., Peraita- Adrados R., Sonka K., Billiard M., Tafti M. (2002). Kleine-Levin syndrome: an autoimmune hypothesis based on clinical and genetic analyses. Neurology, 59(11), 1739-1745.
  • Arnulf I., Groos E., Dodet P. (2018). Kleine-Levin syndrome: A neuropsychiatric disorder. Rev Neurol (Paris), 174(4), 216-227.
  • Leu-Semenescu S., Le Corvec T., Groos E., Lavault S., Golmard JL., Arnulf I. (2015). Lithium therapy in Kleine-Levin syndrome: an open-label, controlled study in 130 patients. Neurology, 85(19), 1655-1662.
  • Mayer G. (2015). Lithium treatment of Kleine-Levin syndrome: An advance for a disorder of hypersomnolence. Neurology, 85(19), 1642-1643.
  • Ramdurg S. (2010). Kleine-Levin syndrome: Etiology, diagnosis, and treatment. Ann Indian Acad Neurol, 13(1), 241-246.
  • Iqbal M., Prasad M., Ritey C. (2014). Recurrent encephalopathy? No I'm a sleeping beauty! J Pediatr Neurosci, 9(1), 82-84.

LİTYUM TEDAVİSİNE BELİRGİN SEMPTOMATİK YANIT: BİR KLEİNE-LEVİN SENDROMU OLGUSU

Year 2019, Volume: 2 Issue: 3, 135 - 140, 29.12.2019

Abstract

Kleine-Levin sendromu (KLS), etiyolojisi bilinmeyen ve nadir görülen bir hastalıktır. Patofizyolojik hipotezler arasında hipotalamik disfonksiyon ve santral serotonin ve dopamin metabolizmasındaki anormallikler bulunur. Bazı klinik özellikler ve çalışma bulguları, olası bir otoimmün süreci desteklemektedir. Tanımlanmış kesin bir tedavisi bulunmamakla birlikte, epizodik seyri ve epizotlar sırasındaki bazı davranış özellikleri nedeniyle tedavisinde çeşitli duygudurum düzenleyici ajanlar kullanılmıştır. Lityum bu amaçla kullanılabilen ve etkinliği gösterilmiş bir ajandır. Biz bu olgu sunumunda uzun yıllardır KLS semptomları olan ve geç tanı alan, lityum tedavisinden fayda gören bir kadın hastayı sunduk.

References

  • AlShareef SM., Smith RM., Bahammam AS. (2018). Kleine-Levin syndrome: clues to aetiology. Sleep Breath, 22(3), 613-623.
  • Panda S. (2017). Kleine-Levin syndrome: A neurological rarity. Neurol India, 65(4), 873-878.
  • Dauvilliers Y., Mayer G., Lecendreux M., Neidhart E., Peraita- Adrados R., Sonka K., Billiard M., Tafti M. (2002). Kleine-Levin syndrome: an autoimmune hypothesis based on clinical and genetic analyses. Neurology, 59(11), 1739-1745.
  • Arnulf I., Groos E., Dodet P. (2018). Kleine-Levin syndrome: A neuropsychiatric disorder. Rev Neurol (Paris), 174(4), 216-227.
  • Leu-Semenescu S., Le Corvec T., Groos E., Lavault S., Golmard JL., Arnulf I. (2015). Lithium therapy in Kleine-Levin syndrome: an open-label, controlled study in 130 patients. Neurology, 85(19), 1655-1662.
  • Mayer G. (2015). Lithium treatment of Kleine-Levin syndrome: An advance for a disorder of hypersomnolence. Neurology, 85(19), 1642-1643.
  • Ramdurg S. (2010). Kleine-Levin syndrome: Etiology, diagnosis, and treatment. Ann Indian Acad Neurol, 13(1), 241-246.
  • Iqbal M., Prasad M., Ritey C. (2014). Recurrent encephalopathy? No I'm a sleeping beauty! J Pediatr Neurosci, 9(1), 82-84.
There are 8 citations in total.

Details

Primary Language Turkish
Subjects ​Internal Diseases
Journal Section Articles
Authors

Elvan Çiçekçi This is me 0000-0003-1039-3840

Mehmet Hamdi Örüm 0000-0002-4154-0738

Publication Date December 29, 2019
Submission Date August 3, 2019
Published in Issue Year 2019 Volume: 2 Issue: 3

Cite

APA Çiçekçi, E., & Örüm, M. H. (2019). LİTYUM TEDAVİSİNE BELİRGİN SEMPTOMATİK YANIT: BİR KLEİNE-LEVİN SENDROMU OLGUSU. Izmir Democracy University Health Sciences Journal, 2(3), 135-140.

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