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Keçilerde Klasik ve Uzun Etkili (LA) Sefkuinom Formülasyonlarının Farmakokinetiklerinin Karşılaştırılması

Year 2020, Volume: 13 Issue: 1, 70 - 75, 30.06.2020

İbrahim Ozan Tekeli Erdinç Türk

Abstract

Bu araştırmanın amacı sefkuinomun %2.5 (klasik) ve %7.5’luk (uzun etkili-LA) formülasyonlarının keçilerde kas içi (IM) uygulanmasını takiben farmakokinetiklerini karşılaştırmaktır. Araştırmada, 6 adet sağlıklı erkek Kilis keçisi kullanıldı. Çalışma, uygulamalar arası 15 günlük ilaç arınma süresini takiben iki aşamada çapraz farmakokinetik dizayna göre gerçekleştirildi. Çalışmanın birinci aşamasında 3 keçiye %2.5’luk diğer 3 keçiye de %7.5’luk sefkuinom formülasyonu IM yolla 2 mg/kg tek doz uygulandı. İkinci aşamada ise keçiler farklı formülasyonları alacak şekilde değiştirildi. Kan örnekleri uygulamayı takiben 0 (kontrol), 5, 10, 15, 20, 30 ve 45. dakikalar ile 1, 2, 3, 4, 5, 6, 8, 10, 12, 24, 48 ve 72. saatlerde alındı. Plazma sefkuinom konsantrasyonları yüksek performanslı sıvı kromatografisi (HPLC)-UV kullanılarak ölçüldü ve farmakokinetik parametreler non-kompartmantel analiz ile hesaplandı. Keçilere %2.5’luk sefkuinom uygulamasını takiben ortalama eliminasyon yarılanma ömrü (t1/2ʎz), eğri altında kalan alan (EAA0-son), plazma doruk konsantrasyon (Cdoruk) ve doruk konsantrasyona ulaşma süresi (Tdoruk) sırasıyla 9.230.45 saat, 15.171.23 saat*µg/mL, 2.630.15 µg/mL ve 1 saat idi. Sefkuinomun %7.5’luk formülasyonunun uygulaması sonrası t1/2ʎz’nin (62.355.06) uzadığı, EAA0−son (33.312.00) ve Tdoruk (6) değerlerinin arttığı ve Cdoruk’un (0.82  0.04) azaldığı belirlendi. Sonuç olarak %2.5’luk formülasyon ile %7.5’luk formülasyon karşılaştırıldığında sefkuinomun farmakokinetiğinde önemli farklılıklar olduğu belirlendi. Fakat keçilerde bakteriyel hastalık durumunda sefkuinomun klasik (%2.5) ve LA (%7.5) formülasyonlarının farmakokinetik ve farmakodinamik etkilerinin ortaya konulmasına ihtiyaç vardır.

Keywords

Farmakokinetik keçi sefkuinom uzun etkili formülasyon

Thanks

Çalışmanın laboratuvar aşamasında verdikleri destekten dolayı Doç. Dr. Orhan Çorum ve Prof. Dr. Kamil Üney’e teşekkür ederiz.

References

  • 1. Mason IS, Kietzmann M. (1999). Cephalosporins–pharmacological Basis of Clinical Use in Veterinary Dermatology. Vet Dermatol. 10(3): 187–192.
  • 2. Hornish RE, Katarski SF. (2002). Cephalosporins in Veterinary Medicine-Ceftiofur Use in Food Animals. Curr Top Med Chem. 2(7): 717–731.
  • 3. Limbert M, Isert D, Klesel N. et al. (1991). Antibacterial Activities in Vitro and in Vivo and Pharmacokinetics of Cefquinome (HR 111V), a New Broad-Spectrum Cephalosporin. Antimicrob Agents Chemother. 35: 14–19.
  • 4. Chin NX, Gu JW, Fang W, Neu HC. (1992). In Vitro Activity of Cefquinome, a New Cephalosporin, Compared with Other Cephalosporin Antibiotics. Diagn Microbiol Infect Dis. 15(4): 331–337.
  • 5. Murphy SP, Erwin ME, Jones RN. (1994). Cefquinome (HR 111V) in Vitro Evaluation of a Broad-Spectrum Cephalosporin Indicated for Infections in Animals. Diagn Microbiol Infect Dis. 20(1): 49–55.
  • 6. CVMP. (2003). Committee for Veterinary Medicinal Products: Cefquinome (Extension to horses) Summary Report (3). EMEA/MRL/883/03. Erişim: https://www.ema.europa.eu/en/documents/mrl-report/cefquinome-extension-horses-summary-report-3-committee-veterinary-medicinal-products_en.pdf. Erişim Tarihi: 25.02.2020.
  • 7. Anonim. (2020). Erişim: http://www.cobactan.com/Product-Introduction.asp Erişim Tarihi: 13.04.2020.
  • 8. Corum O, Corum DD, Er A, Uney K. (2019a). Pharmacokinetics of Cefquinome after Single and Repeated Subcutaneous Administrations in Sheep. J Vet Pharmacol Ther. 42(6): 647–653.
  • 9. Dumka VK, Dinakaran V, Bibhuti R, Satyavan R. (2013). Comparative Pharmacokinetics of Cefquinome Following Intravenous and Intramuscular Administration in Goats. Small Rumin Res. 113: 273–277.
  • 10. Mondea CC, Gyéresi Á. (2010). Pharmacokinetic Study of the Cefuroxime Sodium and the Cefquinome Sulphate in Cattle Plasma by Liquid Chromatography/Mass Spectrometry. Acta Med Marisiensis. 56(5): 453–456.
  • 11. Corum O, Yildiz R, Ider M, Altan F, Ok M, Uney K. (2019b). Pharmacokinetics and Bioavailability of Cefquinome and Ceftriaxone in Premature Calves. J Vet Pharmacol Ther. 42(6): 632–639.
  • 12. Uney K, Altan F, Elmas M. (2011). Development and Validation of a High-Performance Liquid Chromatography Method for Determination of Cefquinome Concentrations in Sheep Plasma and Its Application to Pharmacokinetic Studies. Antimicrob Agents Chemother. 55(2): 854–859.
  • 13. Delis G, Batzias G, Theodosiadou E, Kounenis G, Koutsoviti‐Papadopoulou M. (2009). Influence of the Injection Site on the Pharmacokinetics of Amoxicillin after Intramuscular Administration of a Conventional and a Long‐Acting Formulation in Sheep. J Vet Pharmacol Ther. 32(5): 457–464.
  • 14. Toutain PL, Raynaud JP. (1983). Pharmacokinetics of Oxytetracycline in Young Cattle: Comparison of Conventional vs Long-Acting Formulations. Am J Vet Res. 44(7): 1203–1209.
  • 15. Mestorino N, Marchetti ML, Lucas MF. et al. (2016). Bioequivalence Study of Two Long-Acting Formulations of Oxytetracycline Following Intramuscular Administration in Bovines. Front Vet Sci. 3: 50.
  • 16. Aktas İ, Yarsan E. (2017). Pharmacokinetics of Conventional and Long-Acting Oxytetracycline Preparations in Kilis Goat. Front Vet Sci. 4: 229.
  • 17. Fernández-Varón E, Cárceles-García C, Serrano-Rodríguez JM, Cárceles-Rodríguez CM. (2016). Pharmacokinetics (PK), Pharmacodynamics (PD), and PK-PD Integration of Ceftiofur after a Single Intravenous, Subcutaneous and Subcutaneous-LA Administration in Lactating Goats. BMC Vet Res. 12(1): 232.
  • 18. Wernick MB, Müntener CR. (2010). Cefovecin: a New Long-Acting Cephalosporin. J Exot Pet Med. 19(4): 317–322.
  • 19. Banting ADL, Baggot JD. (1996). Comparison of the Pharmacokinetics and Local Tolerance of Three Injectable Oxytetracycline Formulations in Pigs. J Vet Pharmacol Ther. 19(1): 50–55.
  • 20. Vargas D, Gutierrez L, Juárez I, Gonzalez F, Sumano H. (2008). Pharmacokinetics after Administration of an Injectable Experimental Long-Acting Parenteral Formulation of Doxycycline Hyclate in Goats. Am J Vet Res. 69(8): 1085–1090.
  • 21. Gutiérrez L, Velasco ZH, Vázquez C, Vargas D, Sumano H. (2012). Pharmacokinetics of an Injectable Long-Acting Formulation of Doxycycline Hyclate in Dogs. Acta Vet Scand. 54(1): 35.
  • 22. Albarellos GA, Montoya L, Quaine PC, Landoni MF. (2011). Pharmacokinetics and Bioavailability of a Long-Acting Formulation of Cephalexin after Intramuscular Administration to Cats. Res Vet Sci. 91(1): 129–131.
  • 23. El-Hewaity M, Abd El Latif A, Soliman A, Aboubakr M. (2014). Comparative Pharmacokinetics of Cefquinome (Cobactan 2.5%) Following Repeated Intramuscular Administrations in Sheep and Goats. J Vet Med. 2014: 949642.
  • 24. Champawat M, Sankhala LN, Sharma P, Gaur A. (2018). Effect of Flunixin Co-Administration on Pharmacokinetics of Cefquinome Following Intramuscular Administration in Goats. The Pharma Innovation Journal. 7(5): 480–485.
  • 25. Venkatachalam D, Dumka VK, Ranjan B. (2018). Pharmacokinetics of a Single Intramuscular Injection of Cefquinome in Buffalo Calves. J Vet Pharmacol Ther. 41(1): 155–158.
  • 26. Lu GF, Yang HF, Li YJ, Jiang CM. (2007). Pharmacokinetics of Cefquinome Sulfate Suspension in Pigs. Journal-Yangzhou University Agricultural and life sciences edition. 28(4): 18.
  • 27. Hamed E, Mahmoud FA, Altohamy DE. (2016). Pharmacokinetics of Cefquinome Following Multiple Doses Intramuscular Administration in Goats Using HPLC. Jpn J Vet Res. 64(2): S109–S115.
  • 28. Xie W, Zhang X, Wang T, Du S. (2013). Pharmacokinetic Analysis of Cefquinome in Healthy Chickens. Br Poult Sci. 54(1): 81–86.

Year 2020, Volume: 13 Issue: 1, 70 - 75, 30.06.2020

İbrahim Ozan Tekeli Erdinç Türk

Abstract

References

  • 1. Mason IS, Kietzmann M. (1999). Cephalosporins–pharmacological Basis of Clinical Use in Veterinary Dermatology. Vet Dermatol. 10(3): 187–192.
  • 2. Hornish RE, Katarski SF. (2002). Cephalosporins in Veterinary Medicine-Ceftiofur Use in Food Animals. Curr Top Med Chem. 2(7): 717–731.
  • 3. Limbert M, Isert D, Klesel N. et al. (1991). Antibacterial Activities in Vitro and in Vivo and Pharmacokinetics of Cefquinome (HR 111V), a New Broad-Spectrum Cephalosporin. Antimicrob Agents Chemother. 35: 14–19.
  • 4. Chin NX, Gu JW, Fang W, Neu HC. (1992). In Vitro Activity of Cefquinome, a New Cephalosporin, Compared with Other Cephalosporin Antibiotics. Diagn Microbiol Infect Dis. 15(4): 331–337.
  • 5. Murphy SP, Erwin ME, Jones RN. (1994). Cefquinome (HR 111V) in Vitro Evaluation of a Broad-Spectrum Cephalosporin Indicated for Infections in Animals. Diagn Microbiol Infect Dis. 20(1): 49–55.
  • 6. CVMP. (2003). Committee for Veterinary Medicinal Products: Cefquinome (Extension to horses) Summary Report (3). EMEA/MRL/883/03. Erişim: https://www.ema.europa.eu/en/documents/mrl-report/cefquinome-extension-horses-summary-report-3-committee-veterinary-medicinal-products_en.pdf. Erişim Tarihi: 25.02.2020.
  • 7. Anonim. (2020). Erişim: http://www.cobactan.com/Product-Introduction.asp Erişim Tarihi: 13.04.2020.
  • 8. Corum O, Corum DD, Er A, Uney K. (2019a). Pharmacokinetics of Cefquinome after Single and Repeated Subcutaneous Administrations in Sheep. J Vet Pharmacol Ther. 42(6): 647–653.
  • 9. Dumka VK, Dinakaran V, Bibhuti R, Satyavan R. (2013). Comparative Pharmacokinetics of Cefquinome Following Intravenous and Intramuscular Administration in Goats. Small Rumin Res. 113: 273–277.
  • 10. Mondea CC, Gyéresi Á. (2010). Pharmacokinetic Study of the Cefuroxime Sodium and the Cefquinome Sulphate in Cattle Plasma by Liquid Chromatography/Mass Spectrometry. Acta Med Marisiensis. 56(5): 453–456.
  • 11. Corum O, Yildiz R, Ider M, Altan F, Ok M, Uney K. (2019b). Pharmacokinetics and Bioavailability of Cefquinome and Ceftriaxone in Premature Calves. J Vet Pharmacol Ther. 42(6): 632–639.
  • 12. Uney K, Altan F, Elmas M. (2011). Development and Validation of a High-Performance Liquid Chromatography Method for Determination of Cefquinome Concentrations in Sheep Plasma and Its Application to Pharmacokinetic Studies. Antimicrob Agents Chemother. 55(2): 854–859.
  • 13. Delis G, Batzias G, Theodosiadou E, Kounenis G, Koutsoviti‐Papadopoulou M. (2009). Influence of the Injection Site on the Pharmacokinetics of Amoxicillin after Intramuscular Administration of a Conventional and a Long‐Acting Formulation in Sheep. J Vet Pharmacol Ther. 32(5): 457–464.
  • 14. Toutain PL, Raynaud JP. (1983). Pharmacokinetics of Oxytetracycline in Young Cattle: Comparison of Conventional vs Long-Acting Formulations. Am J Vet Res. 44(7): 1203–1209.
  • 15. Mestorino N, Marchetti ML, Lucas MF. et al. (2016). Bioequivalence Study of Two Long-Acting Formulations of Oxytetracycline Following Intramuscular Administration in Bovines. Front Vet Sci. 3: 50.
  • 16. Aktas İ, Yarsan E. (2017). Pharmacokinetics of Conventional and Long-Acting Oxytetracycline Preparations in Kilis Goat. Front Vet Sci. 4: 229.
  • 17. Fernández-Varón E, Cárceles-García C, Serrano-Rodríguez JM, Cárceles-Rodríguez CM. (2016). Pharmacokinetics (PK), Pharmacodynamics (PD), and PK-PD Integration of Ceftiofur after a Single Intravenous, Subcutaneous and Subcutaneous-LA Administration in Lactating Goats. BMC Vet Res. 12(1): 232.
  • 18. Wernick MB, Müntener CR. (2010). Cefovecin: a New Long-Acting Cephalosporin. J Exot Pet Med. 19(4): 317–322.
  • 19. Banting ADL, Baggot JD. (1996). Comparison of the Pharmacokinetics and Local Tolerance of Three Injectable Oxytetracycline Formulations in Pigs. J Vet Pharmacol Ther. 19(1): 50–55.
  • 20. Vargas D, Gutierrez L, Juárez I, Gonzalez F, Sumano H. (2008). Pharmacokinetics after Administration of an Injectable Experimental Long-Acting Parenteral Formulation of Doxycycline Hyclate in Goats. Am J Vet Res. 69(8): 1085–1090.
  • 21. Gutiérrez L, Velasco ZH, Vázquez C, Vargas D, Sumano H. (2012). Pharmacokinetics of an Injectable Long-Acting Formulation of Doxycycline Hyclate in Dogs. Acta Vet Scand. 54(1): 35.
  • 22. Albarellos GA, Montoya L, Quaine PC, Landoni MF. (2011). Pharmacokinetics and Bioavailability of a Long-Acting Formulation of Cephalexin after Intramuscular Administration to Cats. Res Vet Sci. 91(1): 129–131.
  • 23. El-Hewaity M, Abd El Latif A, Soliman A, Aboubakr M. (2014). Comparative Pharmacokinetics of Cefquinome (Cobactan 2.5%) Following Repeated Intramuscular Administrations in Sheep and Goats. J Vet Med. 2014: 949642.
  • 24. Champawat M, Sankhala LN, Sharma P, Gaur A. (2018). Effect of Flunixin Co-Administration on Pharmacokinetics of Cefquinome Following Intramuscular Administration in Goats. The Pharma Innovation Journal. 7(5): 480–485.
  • 25. Venkatachalam D, Dumka VK, Ranjan B. (2018). Pharmacokinetics of a Single Intramuscular Injection of Cefquinome in Buffalo Calves. J Vet Pharmacol Ther. 41(1): 155–158.
  • 26. Lu GF, Yang HF, Li YJ, Jiang CM. (2007). Pharmacokinetics of Cefquinome Sulfate Suspension in Pigs. Journal-Yangzhou University Agricultural and life sciences edition. 28(4): 18.
  • 27. Hamed E, Mahmoud FA, Altohamy DE. (2016). Pharmacokinetics of Cefquinome Following Multiple Doses Intramuscular Administration in Goats Using HPLC. Jpn J Vet Res. 64(2): S109–S115.
  • 28. Xie W, Zhang X, Wang T, Du S. (2013). Pharmacokinetic Analysis of Cefquinome in Healthy Chickens. Br Poult Sci. 54(1): 81–86.
There are 28 citations in total.

Details

Primary Language Turkish
Subjects Veterinary Surgery
Journal Section Research
Authors

İbrahim Ozan Tekeli 0000-0002-6845-2279

Erdinç Türk 0000-0003-1735-1774

Publication Date June 30, 2020
Acceptance Date June 21, 2020
Published in Issue Year 2020 Volume: 13 Issue: 1

Cite

APA Tekeli, İ. O., & Türk, E. (2020). Keçilerde Klasik ve Uzun Etkili (LA) Sefkuinom Formülasyonlarının Farmakokinetiklerinin Karşılaştırılması. Dicle Üniversitesi Veteriner Fakültesi Dergisi, 13(1), 70-75.
AMA Tekeli İO, Türk E. Keçilerde Klasik ve Uzun Etkili (LA) Sefkuinom Formülasyonlarının Farmakokinetiklerinin Karşılaştırılması. Dicle Üniv Vet Fak Derg. June 2020;13(1):70-75.
Chicago Tekeli, İbrahim Ozan, and Erdinç Türk. “Keçilerde Klasik Ve Uzun Etkili (LA) Sefkuinom Formülasyonlarının Farmakokinetiklerinin Karşılaştırılması”. Dicle Üniversitesi Veteriner Fakültesi Dergisi 13, no. 1 (June 2020): 70-75.
EndNote Tekeli İO, Türk E (June 1, 2020) Keçilerde Klasik ve Uzun Etkili (LA) Sefkuinom Formülasyonlarının Farmakokinetiklerinin Karşılaştırılması. Dicle Üniversitesi Veteriner Fakültesi Dergisi 13 1 70–75.
IEEE İ. O. Tekeli and E. Türk, “Keçilerde Klasik ve Uzun Etkili (LA) Sefkuinom Formülasyonlarının Farmakokinetiklerinin Karşılaştırılması”, Dicle Üniv Vet Fak Derg, vol. 13, no. 1, pp. 70–75, 2020.
ISNAD Tekeli, İbrahim Ozan - Türk, Erdinç. “Keçilerde Klasik Ve Uzun Etkili (LA) Sefkuinom Formülasyonlarının Farmakokinetiklerinin Karşılaştırılması”. Dicle Üniversitesi Veteriner Fakültesi Dergisi 13/1 (June 2020), 70-75.
JAMA Tekeli İO, Türk E. Keçilerde Klasik ve Uzun Etkili (LA) Sefkuinom Formülasyonlarının Farmakokinetiklerinin Karşılaştırılması. Dicle Üniv Vet Fak Derg. 2020;13:70–75.
MLA Tekeli, İbrahim Ozan and Erdinç Türk. “Keçilerde Klasik Ve Uzun Etkili (LA) Sefkuinom Formülasyonlarının Farmakokinetiklerinin Karşılaştırılması”. Dicle Üniversitesi Veteriner Fakültesi Dergisi, vol. 13, no. 1, 2020, pp. 70-75.
Vancouver Tekeli İO, Türk E. Keçilerde Klasik ve Uzun Etkili (LA) Sefkuinom Formülasyonlarının Farmakokinetiklerinin Karşılaştırılması. Dicle Üniv Vet Fak Derg. 2020;13(1):70-5.
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